Discovery of Ferchel and Phenylhry
February 25, 2020 05:43 Source: "China Social Sciences", February 25, 2020, Total No. 1872 Author: Zhang Qingjian

■ German chemist Feichel

Emil Fischer,German chemist,Etaccharide、Enzyme、Purine、amino acids and proteins are widely、In -depth research,The foundation for chemistry for biochemical chemistry。1902,Ferchel won the Nobel Prize in Chemistry,Become the first organic chemist to get this honor。

Ferchel was born in Bonn, Germany on October 9, 1852。1874,Under the guidance of A.von Beayer,Complete the paper "Fluorescence and Moss Moss",Get a doctorate degree,Become the youngest doctorate in Strasbourg's history in history。After graduation,Staying in school as a assistant teaching,Mainly engaged in the preparation of organic matter。Soon after,Fercheal found benzal,This extremely useful compound later became bet365 best casino games a powerful weapon for Fercheal to study sugar。Phenylene is a identification、Excellent reagents for purifying aldosterone, especially sugar,It is also a synthetic dye、Drugs and other organic intermediates important raw materials。Ferchel's benzone that accidentally discovered,It has an important impact on his entire scientific career。

1874,Ferchel arranged intern with dinamine (H2N (C6H4) 2NH2),Through heavy nitrogen reaction,Preparation of phenol (4,4′ -dihydroxybolben benzene)。But what you get is a mixed product。Fercheal repeated and verified the student's experiment。Fercheal and Bayer cannot explain this unexpected result。Ferchel's error speculation,Perhaps it is due to oxidation failure。So,Fercheal adds potassium sulfate in the reactant,Experiments again。But,What you get is a kind of precipitation,Still not the predicted phenyl。

Fergail thinks,The emergence bet365 Play online games of precipitation,It may be related to the pH value of the solution。So,He replaces the simple nitrate nitrogen benzene with a more simple nitrogen,,Use acidified potassium hydrogen sulfate instead of neutral sulfate,Exploration experiments。He gets a salt (that is, potassium phenylsulfate),Treatment with benzollchrium,Generate two phenyl -based phenylphenyl (C6H5NHN (COC6H5) 2) 2)。Then hydrolyze in the hydrochloric acid solution,Forms a phenolic hydrochloride precipitation (C6H5NHNH2 · HCI),Action with KOH。early 1875,23 -year -old Ferchel has gained the first major discovery in his life,lying alkaline (C6H5NHNH2)。

Actually,Before Ferchel,There are two research teams through a similar response to Ferchel,derivatives that have been prepared by phenylin。1869,Schmidt (R. Schmitt) and Glutz (potassium glutz) with potassium sulfate treatment of 4-hydroxyl nitrate,Bet365 app download Get a yellow salt (HOC6H4N2SO3K)。Two years later (1871),A. Strecker (A. Strecker) and P. Romer (P. Romer) potassium hydrogen sulfate and a nitric acid degenerate,Get a colorless salt (C6H5NHNHSO3K)。Unfortunately,They lack the keen insight as Ferchel,I know nothing about my discovery,Therefore, the discovery of the important compound with the phenylhon。

1875,Ferchel in his first paper about phenylin,Give the unknown maternal compound H2NNH2,named "Hydrazine" (肼)。12 years later,T. Curtius prepare this compound,Named "Diamide" (symbol)。Autumn of 1875,Fercheal went to the University of Munich with Bayer,Continue to study the derivatives of his newly discovered benzene。In this process,Ferchel clarified the structure of phenylin。With the help of L. Knorr,Fercheal's effects of phenylpedine and acetylthinate,The first synthetic thermal degradant Antidelin,Stimulated the development of the Bet365 lotto review synthetic drug industry。other,Ferchel phenylin and ketone and ketone contraction,Synthetic 吲哚。

1884,Fercheal discovered benzene and aldehyde、ketone reactions generate crystal crystal solid compound benzene,There is a fixed melting point for phenylpin。Subsequent,It is found that a phenylin and sugar also react,Not only can it generate 腙,腙 can also react with phenylin,Generate 脎。脎 腙 腙,Is a crystallized compound,There is a fixed melting point。So,Phenylpanga has important value in the identification of sugar。Later,Fercheal also uses phenylpylene to determine the configuration of sugar。Study on sugar,It also prompted him to further study other carbohydrates,This allows him to win the Nobel Prize in 1902。

Phenylene is Ferchel's best love,However, it is not all the blessings brought to him。Divided contact with toxic phenylin for many years,seriously Bet365 app download damaged his health,pneumonia、Digestion、bronchitis、Insomnia、laryngealitis, etc. constantly tortured him。First War brought him endless pain,The body is down,Two sons died in non -life。early July 1919,He was diagnosed with intestinal cancer。July 15, 1919,Unbearable torture of illness,A generation of scientific great men Ferdier, who served hydrocylic acid in Berlin's own apartment and committed suicide,67 years old。

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